<html><head><style type='text/css'>p { margin: 0; }</style></head><body><div style='font-family: Arial; font-size: 10pt; color: #000099'><span></span><b>From: </b>"Carolyn Johnson" <cjohnson@mbl.edu><br><br><style>p { margin: 0; }</style><div style="font-family: Arial; font-size: 12pt; color: rgb(0, 0, 0);">
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<h1 style="line-height: 22px; margin-top: -0.1em; font-family: Arial,Helvetica,sans-serif; color: rgb(5, 33, 85); font-size: 17px; font-weight: bold; text-decoration: none;">Mechanisms of PAH Developmental Toxicity and Evolved Resistance: The Elizabeth River Killifish Story</h1></td>
<td style="line-height: 16px; margin-top: 6px; font-family: Arial,Helvetica,sans-serif; font-size: 12px;" align="right" valign="top"><br></td></tr></tbody></table></td></tr></tbody></table>
<span style="font-variant: normal; margin-top: 0px; font-family: Arial,Helvetica,sans-serif; margin-bottom: 0px; color: rgb(0, 102, 153); font-size: 13px; font-weight: bold; padding-top: 0px;" class="subhead"><strong><span class="Object" id="OBJ_PREFIX_DWT13">Thursday, June 30</span>, 2011</strong><br>Redfield Auditorium - 12:00 Noon<br>Dr. Richard Di Giulio<br>Professor Nicholas School of the Environment, Duke University</span><br><br>
<p style="line-height: 16px; margin-top: 6px; font-family: Arial,Helvetica,sans-serif; font-size: 12px;">Portions
of the Elizabeth River, an estuary in southeastern Virginia, are highly
contaminated with polycyclic aromatics hydrocarbons (PAHs), largely as a
result of former wood-treatment plants that employed creosote. The most
studied portion of the river in terms of contamination is the Atlantic
Wood Industries Superfund site. A population of Atlantic killifish or
mummichog (<em>Fundulus heteroclitus</em>) inhabiting this site display
elevated rates of liver cancer, not surprising in light of the levels of
carcinogenic PAHs present there. However, they display a remarkable
resistance to the acute effects of PAHs such as larval and
embryotoxicity, compared to killifish populations from relatively
uncontaminated sites. This presentation will discuss mechanisms
underlying this adaptation to pollution as well as evolutionary
consequences and considerations relevant to remediation of the Elizabeth
River. Additionally, mechanisms by which PAHs perturb embryonic
development, addressed with both the killifish and zebrafish models,
will be discussed.</p></span><br><span><br><span></span><div><div><div>
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<div>Mark Hahn <<span class="Object" id="OBJ_PREFIX_DWT12"><a href="mailto:mhahn@whoi.edu" target="_blank">mhahn@whoi.edu</a></span>>
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