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<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB">A two year post doctoral position is available ,
starting in 2014 in the Centre de Biologie du Développement, UMR 5547 in the
team <i style="mso-bidi-font-style:normal">Function of calcium signalling in
stem cell regulation </i>directed by Catherine Leclerc and Marc Moreau. (</span><a href="http://www-cbd.ups-tlse.fr/spip.php?rubrique43"><span style="font-size:12.0pt;mso-ansi-language:EN-GB" lang="EN-GB">http://www-cbd.ups-tlse.fr/spip.php?rubrique43</span></a><span style="font-size:12.0pt;mso-ansi-language:EN-GB" lang="EN-GB">)</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB"> </span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB">Our group tackles fundamental question related to <span style="mso-bidi-font-weight:bold">understanding how Ca<sup>2+</sup> signalling
controls stemness in neural and cancer stem cells of the brain tumour
glioblastoma. Our aim is to investigate how abnormalities in Ca<sup>2+</sup>
homeostasis affect the dynamics and progression of glioblastoma-related
properties. </span></span><span style="font-size:12.0pt;mso-bidi-font-family:
Tahoma;mso-ansi-language:EN-GB" lang="EN-GB">The comparison of Ca<sup>2+</sup> signalling in
normal and pathological situations should provide better insight of how stem
cell quiescence is regulated.</span><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB"> The results collected will
lead to the establishment of a predictive model for Ca<sup>2+</sup> signalling
to help us understand which elements of the Ca<sup>2+</sup> signalling toolkit
are crucial to the initiation and development of glioblastoma, and are thus
potential targets for therapeutic intervention.</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB">This project is developed
through national and international collaborations (Hong Kong). We use vertebrate
embryos (Xenopus), human cells, calcium imaging, optogenetics, and
developmental genetic tools.</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB"> </span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB">We are looking for an
enthusiastic candidate to help develop this project. Applicants must have a PhD
in developmental or cell biology and have experience with culture of stem
cells, lentivirus manipulation and to be willing to visit the different
laboratories of our collaborators.</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB">Prior experiences with
imaging or optical techniques are desired but not necessary.</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB">Interested candidates should
send curriculum vitae, a brief description of their research training. Two
referees recommendations are needed.</span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB;mso-bidi-font-weight:bold" lang="EN-GB"> </span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB">For applications or more details please contact </span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:
justify;line-height:normal"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB">Marc Moreau (</span><a href="mailto:marc.moreau@univ-tlse3.fr"><span style="font-size:12.0pt;
mso-ansi-language:EN-GB" lang="EN-GB">marc.moreau@univ-tlse3.fr</span></a><span style="font-size:12.0pt;mso-ansi-language:EN-GB" lang="EN-GB">) or Catherine Leclerc (</span><a href="mailto:catherine.leclerc@univ-tlse3.fr"><span style="font-size:12.0pt;mso-ansi-language:EN-GB" lang="EN-GB">catherine.leclerc@univ-tlse3.fr</span></a><span style="font-size:12.0pt;mso-ansi-language:EN-GB" lang="EN-GB">) </span></p>
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<![endif]--><br><br>-- <br><div><span name="x"></span>Marc Moreau<br>Centre de Biologie du Développement<br>UMR 5547<br>Université Paul Sabatier<br>118 rte de Narbonne<br>31062 Toulouse<br>Tél 33 (0)5 61 55 63 98<span name="x"></span><br></div></div></body></html>