<html><body><div style="font-family: verdana,helvetica,sans-serif; font-size: 12pt; color: #000000"><div><div><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Dear Colleagues</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Below are some details and template for the <b>2 letters of support</b> that Xenbase needs from its users. <b>Please email letter to me </b></span><span class="Object"><span class="Object"><a href="mailto:aaron.zorn@cchmc.org" target="_blank" data-mce-href="mailto:aaron.zorn@cchmc.org"><b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">aaron.zorn@cchmc.org</span></b></a></span></span><b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> and I will collate them and pass them on to the NIH. </span></b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">If you have already sent me letter thank you!</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">First letter:</span></b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">As we mentioned at the PIs meeting, due to unforeseen infrastructure problems with the NICHD building, the release of the Program Announcement that would allow us to submit a Xenbase renewal has been substantially delayed. Given the standard timeline for application receipts, study section review and council decisions, renewed funding could not possibly begin until 4-6 month after the end of our current grant. This gap in funding would result a closure of Xenbase and the need to layoff the staff. James Coulombe our program officer at NICHD is aware of the problem and is doing his best to secure at bridge funding. We need your letter of support to keep Xenbase operational.</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Draft letter for bridge funding – please modify to use your own words:</span></p><div style="font-size: 14px; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: windowtext; padding: 0in 0in 1pt;" data-mce-style="font-size: 14px; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: windowtext; padding: 0in 0in 1pt;"><p style="border: none; padding: 0in; margin: 0px;" data-mce-style="border: none; padding: 0in; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p></div><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">James N. Coulombe, Ph.D. Program Director, Developmental Genetics and Systems Developmental Biology Developmental Biology and Structural Variation Branch <i>Eunice Kennedy Shriver</i> National Institute of Child Health and Human Development RM 4B01, MSC 7510 6100 Executive Blvd Bethesda, MD 20892-7510 </span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"></span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Surprised to hear that Xenbase will have a gap in funding </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Urge NICHD to provide necessary bridge funding</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Explain why Xenbase is critical to your NIH (NICHD) – funded research program. Please use specific example of how you use Xenbase and cite your grant numbers.</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">If you have submitted any data to Xenbase please explain how Xenbase’s data sharing infrastructure helps you make your findings available to the community.</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Describe how your productivity might be hampered if Xenbase ceased to exist for 6 months.</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11pt;" data-mce-style="font-size: 11pt;">·<span style="font-size: 7pt; font-family: 'Times New Roman';" data-mce-style="font-size: 7pt; font-family: 'Times New Roman';"> </span></span><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Preserving Xenbase saves resources in the end due to: 1) the need to hire and retrain new Xenbase staff if there is a gap, 2) extra time and money individual labs will need to expend to replicate Xenbase services in each lab if there is gap.</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">-------------------------------</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;"> </span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><b><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Second letter:</span></b></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"><span style="font-size: 11.0pt;" data-mce-style="font-size: 11.0pt;">Peter Vize and I also need a letter of support from you that we will include in the Xenbase renewal application. This letter should not mention bridge funding but support renewal of Xenbase and then just modify the body of the text from the bridge funding letter explain how you use Xenbase in your NIH-funded research using specific examples. Address to:</span></p><p style="font-size: 14px; margin: 0px;" data-mce-style="font-size: 14px; margin: 0px;"> </p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">Peter D. Vize Aaron M. Zorn</span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">Director Xenbase Director Xenbase </span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">Dept. of Biological Science Cincinnati Children’s Hospital</span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">University of Calgary University of Cincinnati</span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">2500 University Drive NW 240 Sabin Way</span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">Calgary, Alberta T2N 1N4 Cincinnati OH 45229 </span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-family: Arial;" data-mce-style="font-family: Arial;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;">Canada phone <span class="Object"><a href="callto:403%20220%208502" data-mce-href="callto:403%20220%208502">403 220 8502</a></span> USA phone <span class="Object"><a href="callto:513%20636%203770" data-mce-href="callto:513%20636%203770">513 636 3770</a></span></span></span></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span size="3" style="font-size: medium;" data-mce-style="font-size: medium;"> </span></p></div></div><div><br></div><div><br></div></div></body></html>