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<title>Introducing XenHead</title>
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<font face="Times New Roman"><span style="font-size:10.5pt">Dear <i>Xenopus</i> community,<br>
</span><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">Michael Levin and I are Co-PIs on a grant from NICHHD that includes funding to create an
<u>Atlas of Normal <i>Xenopus</i> Craniofacial Development</u>. The use of <i>Xenopus</i> to study craniofacial development is increasing, and so is the need for a central repository of what we know. Having such a resource will make it easier for all of us
to do state-of-the-art research in this field and to apply for funding for craniofacial projects. To make sure XenHead gets the best start we can give it, we are soliciting thoughts and ideas from the
<i>Xenopus</i> community. Conversations with researchers have already begun* and we hope for them to continue and expand.<br>
</span><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">Many great databases already exist. The distinguishing characteristics of this one will be:
<br>
</span></font><span style="font-size:10.5pt"><font face="Wingdings">Ø </font><font face="Times New Roman">a focus on the normal development of
<i>Xenopus</i> anterior structures, inside and out;<br>
</font><font face="Wingdings">Ø </font><font face="Times New Roman">multiple images, rather than a single example, to show a realistic range of normal;<br>
</font><font face="Wingdings">Ø </font><font face="Times New Roman">inclusion of anterior/frontal views in addition to dorsal, ventral, and lateral;<br>
</font><font face="Wingdings">Ø </font><font face="Times New Roman">inclusion of physiology in addition to anatomy and genetics;
<br>
</font><font face="Wingdings">Ø </font><font face="Times New Roman">interactive features designed to simplify the collating and exporting of contents that are of interest to you and your students.<br>
</font><font face="Arial"><br>
</font><font face="Times New Roman">We plan for the atlas to comprise two and three dimensional images, videos, and maps, covering stages 12 through 50 in 12 to 15 divisions. Subjects will include: external morphology (out of, and still in, the vitelline envelope),
internal morphology, physiology, RNA and protein expression maps and arrays, and ways to use
<i>Xenopus</i> as a model system for human diseases. One high priority is to entice contributors by making the logistics of contributing as simple as possible. By including multiple illustrations the site will also provide information that cannot be found
in the primary literature. And finally, the site will provide excellent opportunities for students, at any point in their careers, to make tangible contributions to the field.<br>
</font></span><font face="Times New Roman"><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">In addition to the utility of such a collection for research, teaching, and avoiding unnecessary replication of work, the site will also mean opportunities for all of us to make available the thousands of images that already
exist on our computers, but that did not make it into a manuscript.<br>
</span><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">We’d like to hear your thoughts about what would make XenHead a resource that you would use and recommend, and, of course, where you would want to see your work. We are particularly interested in hearing ideas for how to
build this resource so that contributors are not overburdened but information and annotations are clear and accurate.
<br>
</span><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">Please contact me with your thoughts at <a href="Dany.Adams@Tufts.edu">
Dany.Adams@Tufts.edu</a></span><span style="font-size:12pt"> <<a href="mailto:Dany.Adams@Tufts.edu">mailto:Dany.Adams@Tufts.edu</a>>
</span><span style="font-size:10.5pt">. To avoid the spam folder put ‘XenHead’ in the subject line.<br>
Thank you in advance for your input, and please start thinking about what you might want to contribute.<br>
</span><span style="font-size:12pt"><br>
</span><span style="font-size:10.5pt">Dany Spencer Adams and Michael Levin <br>
August 10, 2015<br>
<br>
</span><font size="2"><span style="font-size:10pt">*Thanks again to Christina James-Zorn, Janine Ziermann, David Blackburn, Keith Cheng, Kristin Artinger, Gerhard Schlosser, Anne-Helene Monsouro-Borq, Sally Moody, Jean-Pierre Saint-Jeannet, Karen Liu, Ruchi
Bajpai, Amanda Dickinson, Roberto Mayor, James Hanken, and Aaron Zorn. <br>
</span></font></font><font face="Arial"><span style="font-size:11pt"><br>
-- <br>
Dany Spencer Adams, PhD<br>
Research Associate Professor<br>
Department of Biology, Tufts University<br>
TEL (617) 627-6204<br>
FAX (617) 627-5305<br>
<a href="Dany.Adams@Tufts.edu">Dany.Adams@Tufts.edu</a><br>
<br>
MAILING ADDRESS:<br>
<br>
Dany Adams<br>
Tufts Center for Regenerative and Developmental Biology<br>
200 Boston Avenue, Suite 4600<br>
Medford, MA 02155<br>
<br>
"Err and err and err again, but less and less and less." P. Hein<br>
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