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<p style="margin-top:0;margin-bottom:0"><span style="font-size: 16pt;">Xenbase Newsletter: Summer 2018</span><br>
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<!--[if !supportLists]--><b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red">1.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span></b><!--[endif]--><b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red">New
</span></b><b><span style="font-family: Calibri, sans-serif;">‘Disease Pages’ </span>
</b><b><span style="font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:
minor-latin">increase support for human disease modeling in
<i>Xenopus</i><o:p></o:p></span></b></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; margin: 0in 0in 0.0001pt;">
<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin"><o:p> </o:p></span></b></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; margin: 0in 0in 0.0001pt;">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">To support
<b>Disease modeling and disease gene studies</b>, Xenbase has launched new ‘<b>Disease Pages’</b> for<b> DO</b> (<u>D</u>isease
<u>O</u>ntology) diseases and genetically inherited diseases from <b>OMIM (</b>the
<u>O</u>nline <u>M</u>endelian <u>I</u>nheritance in <u>M</u>an). <o:p></o:p></span></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; margin: 0in 0in 0.0001pt;">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">The
<b>DO Disease Pages</b> cover acquired diseases (e.g., metabolic and mental health disorders), diseases with environmental, infectious, or parasitic causes (e.g. sleeping sickness), developmental disorders (e.g., cleft palate), diseases that have uncharacterized
genetic components (e.g., idiopathic scoliosis), as well as all OMIM diseases. As
<b>the DO is an ontology</b>, we also have DO Disease Pages for broader, parent terms such as ‘cancer’, ‘physical disorder’, and ‘immune system disease’.
<o:p></o:p></span></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; margin: 0in 0in 0.0001pt;">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin"><o:p> </o:p></span></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in;">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin">Xenbase will use the
<b>DO and OMIM to curate disease model research and phenotypes.</b> <o:p></o:p></span></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in;">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><b><span style="font-size:10.0pt;font-family:
"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin">Disease Pages link out to Xenopus
gene pages</span></b><span style="font-size:10.0pt;
font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin">, an ontology viewing service, and to human
disease resources. <o:p></o:p></span></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in;">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size: 10pt; font-family: Calibri, sans-serif; color: rgb(34, 34, 68); background-image: initial; background-">Research articles that are tagged with a DO and/or OMIM term are on the
<b>‘Literature Tab’</b>. </span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin"><o:p></o:p></span></p>
<h3 style="font-family: Calibri, Helvetica, sans-serif, Helvetica, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt; margin: 15pt 0in 7.5pt; text-indent: -0.25in; background-image: initial;">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;font-weight:normal;mso-bidi-font-weight:bold">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size: 10pt; font-family: Calibri, sans-serif;">To find a Disease Page</span><span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;">: Click
<a href="http://www.xenbase.org/common/disease.do?method=search&searchIn=10" style="color: rgb(5, 99, 193); text-decoration: underline;" id="LPlnk666363" class="OWAAutoLink" previewremoved="true">
Search Disease</a> on the Anatomy Tile OR Use the </span><span style="font-size: 10pt; font-family: Calibri, sans-serif;">Quick Search menu</span><span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"> in top corner.
</span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;font-weight:normal;mso-bidi-font-weight:bold"><o:p></o:p></span></h3>
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<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;font-weight:normal;mso-bidi-font-weight:bold">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;">In the Quick Search menu, select
</span><span style="font-size: 10pt; font-family: Calibri, sans-serif;">‘Disease Ontology</span><span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"> (below top) or
</span><span style="font-size: 10pt; font-family: Calibri, sans-serif;">OMIM Diseases</span><span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"> search (below bottom). Type-ahead will match terms, or the ID number, for a disease.
Mouse down to select a specific term or hit Search to return all matches. </span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;font-weight:normal;mso-bidi-font-weight:
bold"><o:p></o:p></span></h3>
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<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"><img size="109700" contenttype="image/jpeg" id="797061_rs|3" style="user-select: none; width: 336px; height: 238.724px;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:237e6925-0ec0-4b2c-a32a-047eb78919e3"><br>
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<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"><img size="120799" contenttype="image/jpeg" id="256677_rs|3" style="user-select: none; width: 338px; height: 279.586px;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:d33669fc-3c49-4732-bc83-f185595d0a67"><br>
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<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"><br>
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<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;">
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><b><span style="font-size:10.0pt;font-family:
"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin">DO Disease Pages</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">
(below top) give a definition and synonyms, have all the curated articles aggregated on
<b>Literature tab</b>, list associated OMIMs, link to other model organism databases (including the AGR =<u>A</u>lliance of
<u>G</u>enome <u>R</u>esources), and link to <b>Xenbase gene pages</b> as well as human disease resources, such as the DO website.
<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><b><span style="font-size:10.0pt;font-family:
"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin">OMIM Disease Pages</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">
(below bottom) link to <b>Xenbase gene pages</b>, to the <b>DO Disease Page</b>, OMIM and specific literature.<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin"><br>
</span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin"><br>
</span></p>
<img size="217712" contenttype="image/jpeg" id="380273_rs|3" style="user-select: none; width: 507px; height: 304.799px;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:285f9691-89c3-4326-b5d8-7bee19adae7f"><br>
<img size="77976" contenttype="image/jpeg" id="img567061" style="user-select: none; width: 508px; height: 219.108px;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:79f71eb1-b06c-4b7a-bf79-7c3db12102d1"><br>
<br>
</span></div>
<div style="font-family: Calibri, Helvetica, sans-serif, Helvetica, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt;">
<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;">
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<b><span style="font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:
minor-latin;color:red">2.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span></b><!--[endif]--><b><span style="font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:
minor-latin;color:red">New
</span></b><b><span style="font-family: Calibri, sans-serif;">Dynamic XAO Anatomy Trees, and updated XAO v6.0 now available for download.</span></b><b><span style="font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red"><o:p></o:p></span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">The Xenopus Anatomy Ontology- aka the XAO -describes embryonic development
in <i>Xenopus</i>, from egg to adult, in a hierarchy. <o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size: 10pt; font-family: Symbol;">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">Use the XAO v6.0 to your single cell
RNA-Seq experiments. Download the latest XAO, v6.0 here: <a href="http://www.xenbase.org/other/static/ftpDatafiles.jsp#Anatomy" style="color: rgb(5, 99, 193); text-decoration: underline;" id="LPlnk855464" class="OWAAutoLink" previewremoved="true">
http://www.xenbase.org/other/static/ftpDatafiles.jsp#Anatomy</a> <o:p></o:p></span><br>
</p>
<p style="margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:10.0pt;font-family:
"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin"><o:p> </o:p></span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin">Our
<b>new Anatomy Trees</b> visualize the ‘is a‘ and, ‘part of’ relationship(s) (see example below for
<a href="http://www.xenbase.org/anatomy/showanatomy.do?method=displayAnatomySummary&anatomyId=11" style="color: rgb(5, 99, 193); text-decoration: underline;" id="LPlnk721638" class="OWAAutoLink" previewremoved="true">
brain</a>).<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin">Explore the XAO v6 Anatomy Trees via
the Anatomy & Development menu/tiles, under the <a href="http://www.xenbase.org/anatomy/anatomy.do?method=display&tabId=2" style="color: rgb(5, 99, 193); text-decoration: underline;" id="LPlnk801546" class="OWAAutoLink" previewremoved="true">Search Anatomy</a>
Tab.<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin">Click blue nodes (with terms to left)
to expand parts of the tree.<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin">Use Expand / Collapse Tree buttons to
fully expand/collapse all nodes. Download the tree view in SVG format.<o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red">Hint!
</span><span style="font-size:
10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:
minor-latin">Read tree from right to left: rhombomere R1, ‘is a’ rhombomere,
is ‘part of’ the hindbrain, which is ‘part of’ the brain. <o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<!--[if !supportLists]--><span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol">·<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span><!--[endif]--><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin">Click underlined terms to open the specific
XAO term page. </span><span style="font-family: Calibri, sans-serif; font-size: 10pt; text-indent: -0.25in;">100’s of terms now have illustrations + marker gene ISH images.</span></p>
</span></div>
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<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"><img size="420948" contenttype="image/jpeg" id="img998744" style="max-width: 99.9%; user-select: none;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:1cfee154-583a-4b9c-b516-9461b9b49ec5"><br>
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<div style="font-family: Calibri, Helvetica, sans-serif, Helvetica, EmojiFont, "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols; font-size: 12pt;">
<span style="font-size: 10pt; font-family: Calibri, sans-serif; font-weight: normal;"><br>
</span></div>
<div style="">
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in;"><span style="color: red;"><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; line-height: normal;"><font face="Calibri, sans-serif"><b>3.</b></font></span><span style="font-family: "Times New Roman"; font-size: 7pt; font-weight: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; line-height: normal;">
</span></span><!--[endif]--><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family: Calibri, sans-serif; color: red;">Download
</span></b><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family: Calibri, sans-serif;">the data from X laevis RNA Seq graphs- new
</span></b><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family:
"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:
minor-latin;mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;
color:red">Save
to CSV </span></b><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family: Calibri, sans-serif;">and </span></b><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red">Save
to SVG</span></b><b style="font-family: "Times New Roman"; font-size: 12pt;"><span style="font-family: Calibri, sans-serif;"> buttons.</span></b><b style="font-family: "Times New Roman"; font-size: 12pt; font-weight: normal;"><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red"><o:p></o:p></span></b></p>
<p style="font-family: "Times New Roman"; font-size: 12pt; font-weight: normal; margin: 0in 0in 0.0001pt;">
<span style="font-size: 10pt; font-family: Calibri, sans-serif; color: rgb(34, 34, 34); background-image: initial; background-">Save the
<b>TPM values</b> for </span><span style="font-size: 10pt; font-family: Calibri, sans-serif;">RNA Seq data</span><span style="font-size: 10pt; font-family: Calibri, sans-serif; color: rgb(34, 34, 34); background-image: initial; background-"> as a
<b><u>c</u>omma-<u>s</u>eparated <u>v</u>alues (CSV) file</b>, or the graph as <b>
a <u>S</u>calable <u>V</u>ector <u>G</u>raphic (SVG) file</b>. <o:p></o:p></span></p>
<img size="128231" contenttype="image/jpeg" id="img404749" style="max-width: 99.9%; user-select: none;" tabindex="0" data-outlook-trace="F:1|T:1" src="cid:2024eae3-abc2-485b-94ef-87e8e9857b01"><br>
<br>
</div>
<div style="">
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red">4.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";">
</span></span></b><!--[endif]--><b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red">Xenbase v 4.9.2 launched in June 2018. </span></b></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red"> </span></b></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red"><span style="color: rgb(0, 0, 0);">Contact us: </span><a href="mailto:xenbase@ucalgary.ca" style="color: rgb(5, 99, 193); text-decoration: underline;" id="LPlnk663325" class="OWAAutoLink" previewremoved="true"><span style="color: rgb(0, 111, 201);">xenbase@ucalgary.ca</span></a><span style="color: rgb(0, 0, 0);">
with comments or questions.</span><o:p></o:p></span></b></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<b><span style="font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:red"><br>
</span></b></p>
<p style="margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:9.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:red"><span style="font-size: 12pt; color: rgb(0, 0, 0);">If
Xenbase contributes to your research, </span><b><span style="font-size: 12pt; color: rgb(0, 0, 0);">please</span></b><span style="font-size: 12pt; color: rgb(0, 0, 0);">
</span><b><span style="font-size: 12pt; color: rgb(0, 0, 0);">cite our latest papers</span></b><span style="font-size: 12pt; color: rgb(0, 0, 0);">
</span><span style="font-size: 12pt;"><b><span style="color: rgb(0, 0, 0);">AND our RRID.
</span></b><span style="color: rgb(0, 0, 0);">C</span></span><span style="font-size: 12pt; color: rgb(0, 0, 0);">itations will help us get our NIH funding!</span><o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:8.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin"><span style="font-size: 12pt;">- Karimi K. et al. (2018).
</span><b><span style="font-size: 12pt;">Nucleic Acids Res. 2018 Jan 4;46(D1)</span><span style="font-size: 12pt;">:D861-D868</span></b><span style="font-size: 12pt;">.
</span><span style="font-size: 12pt;">doi</span><span style="font-size: 12pt;">: 10.1093/nar/gkx936. PMID: 29059324.</span><o:p></o:p></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size: 8pt; font-family: Calibri, sans-serif;"><span style="font-size: 12pt;">- James-Zorn C. et al. (2018)
</span><b><span style="font-size: 12pt;">Navigating Xenbase: An Integrated Xenopus G</span></b></span><b><span style="font-size: 12pt; font-family: Calibri, sans-serif;">enomics and Gene Expression Database</span></b><i><span style="font-size: 12pt; font-family: Calibri, sans-serif;">.</span></i><span style="font-size:8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin"><span style="font-size: 12pt;">
</span><i><span style="font-size: 12pt;">In:</span></i><span style="font-size: 12pt;"> Kollmar M. (ed) Eukaryotic Genomic Databases. Methods in Molecular Biology, vol 1757. Humana Press, New York, NY.</span><i><span style="color: rgb(0, 176, 240); font-size: 12pt;"> </span></i></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size:8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin"><i><span style="color:red"><span style="font-size: 12pt;">
<span style="color: rgb(0, 111, 201);">Download the book in p</span><span style="color: rgb(0, 111, 201);" class="">df</span><span style="color: rgb(0, 111, 201);"> format</span></span><span style="font-size: 12pt; color: rgb(0, 111, 201);" class=""> from</span><span style="font-size: 12pt; color: rgb(0, 111, 201);">
here: doi.org/10.1007/978-1-4939-7737-6_10.</span></span><span style="color:#00B0F0"><o:p></o:p></span></i></span></p>
<p style="text-indent: -0.25in; margin: 0in 0in 0.0001pt 0.5in; font-size: 12pt; font-family: "Times New Roman";">
<span style="font-size: 12pt; font-family: Calibri, sans-serif;">- Xenbase (www.xenbase.org, RRID:SCR_003280).<o:p></o:p></span></p>
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