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<p class="MsoNormal"><span style="font-size:11.0pt">Dear Xenopus community,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> Please find below an email from Sally Moody and Abraham Fainsod.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Marko<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Dear Xenopus Community<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">We are compiling a book titled
<b>“Xenopus, from basic biology to disease models in the genomic era”</b>, to be published by Taylor and Francis CRC Press. The purpose of this book is to review the contributions of Xenopus as an experimental system to many fields of biology, including but
not limited to cell biology, gene regulation, biochemistry, neurobiology, developmental biology and genomics. We envision that chapters will be a resource on the usefulness of the Xenopus experimental system for community members, as well as biomedical researchers
using other models. We wish to include the classical and novel approaches developed in the Xenopus system and emphasize its usefulness for solving pressing biomedical issues related to human health.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">We are writing to the Xenopus community to suggest topics as well as to contribute chapters to this important project. We include below a preliminary Table of Contents that includes
chapters we believe must be included. We are seeking contributors for these chapters, but in addition invite your suggestions for additional chapters. We would like each chapter to include an historical perspective, a summary of the field up until recent years,
a current state of the field including your own work and outlooks for the future.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">We would appreciate your suggestions and a note on whether you are interested in contributing by May 15<sup>th</sup>, 2020 so we can finalize the ToC. We would like chapters
to be submitted by January 2021. We are very excited to lead this project and to have your expertise represented.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">With very best wishes,
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Abraham Fainsod, Hebrew University of Jerusalem (</span><a href="mailto:abraham.fainsod@mail.huji.ac.il"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;background:white">abraham.fainsod@mail.huji.ac.il</span></a><span style="font-size:10.5pt;font-family:"Arial",sans-serif">)
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Sally Moody, George Washington University (</span><a href="mailto:samoody@gwu.edu"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">samoody@gwu.edu</span></a><span style="font-size:10.5pt;font-family:"Arial",sans-serif">)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><i><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Xenopus</span></i></b><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">: from basic biology to disease models in the genomic era<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Preliminary ToC</span></b><u><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></u></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Section I: Contributions to Cell, Developmental and Molecular Biology<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black">This section should emphasize the contributions that
<i>Xenopus</i> has made to basic cell, developmental and molecular biology summarizing past contributions, current research and future directions.
</span><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 1:</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"> Amphibian contributions to experimental embryology,
including: (a) Classical: Morgan, Harrison, Spemann, Roux; (b) Introduction of Xenopus to the field of experimental biology; (c) Work leading to current research in molecular developmental biology and regeneration.
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 2:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Cell cycle and<b>
</b>the discovery of cell cycle components. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 3:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Maternal gene control of embryogenesis, including germ layer formation.
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 4:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Signaling pathways in dorsal-ventral patterning including the Organizer.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 5:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Signaling pathways in<b>
</b>anterior-posterior patterning. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 6:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Signaling pathways (e.g., Wnt PCP) regulating morphogenetic movements.
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><u><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p><span style="text-decoration:none"> </span></o:p></span></u></p>
<p class="MsoNormal" style="margin-left:.25in;text-indent:-.25in"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 7:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Forces, cell shape changes and stress that regulate<b>
</b></span><span style="font-size:10.5pt;font-family:"Arial",sans-serif">morphogenetic movements, cell division and signaling pathways (including Hippo pathway).
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 8:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">The regulation of neural crest cell differentiation and migration.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 9:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Using<b>
</b>oocytes for functional analysis of membrane and secreted proteins.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Section II: From Basic Biological Insights to Human Disease<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black">This section should emphasize the advantages of
<i>Xenopus</i> in biomedical research and the efforts to elucidate the etiology of human disease and to establish human disease models including regeneration.</span><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:red">
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">About 10 chapters suggested by the community<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Section III:
</span></b><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Systems Biology and the Genomic Era</span></b><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">This section should emphasize system level approaches implemented in Xenopus to understand basic biological processes and human disease.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 20:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Systems biology analyses of Xenopus embryogenesis<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 21:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chromatin assembly and epigenetics<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 22:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Quantitative proteomics<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 23:
</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Xenopus genome<b>
</b>evolution<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><b><o:p></o:p></b></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Chapter 24</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">: Advances in genome manipulation and editing<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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