<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Verdana;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:"Times New Roman \(Body CS\)";
panose-1:2 11 6 4 2 2 2 2 2 4;}
@font-face
{font-family:"Segoe UI";
panose-1:2 11 6 4 2 2 2 2 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin-top:0in;
margin-right:0in;
margin-bottom:.2pt;
margin-left:-17.5pt;
text-indent:-.5pt;
line-height:122%;
font-size:12.0pt;
font-family:"Verdana",sans-serif;
color:black;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
p.MsoListParagraph, li.MsoListParagraph, div.MsoListParagraph
{mso-style-priority:34;
margin-top:0in;
margin-right:0in;
margin-bottom:.2pt;
margin-left:.5in;
mso-add-space:auto;
text-indent:-.5pt;
line-height:122%;
font-size:12.0pt;
font-family:"Verdana",sans-serif;
color:black;}
p.MsoListParagraphCxSpFirst, li.MsoListParagraphCxSpFirst, div.MsoListParagraphCxSpFirst
{mso-style-priority:34;
mso-style-type:export-only;
margin-top:0in;
margin-right:0in;
margin-bottom:0in;
margin-left:.5in;
mso-add-space:auto;
text-indent:-.5pt;
line-height:122%;
font-size:12.0pt;
font-family:"Verdana",sans-serif;
color:black;}
p.MsoListParagraphCxSpMiddle, li.MsoListParagraphCxSpMiddle, div.MsoListParagraphCxSpMiddle
{mso-style-priority:34;
mso-style-type:export-only;
margin-top:0in;
margin-right:0in;
margin-bottom:0in;
margin-left:.5in;
mso-add-space:auto;
text-indent:-.5pt;
line-height:122%;
font-size:12.0pt;
font-family:"Verdana",sans-serif;
color:black;}
p.MsoListParagraphCxSpLast, li.MsoListParagraphCxSpLast, div.MsoListParagraphCxSpLast
{mso-style-priority:34;
mso-style-type:export-only;
margin-top:0in;
margin-right:0in;
margin-bottom:.2pt;
margin-left:.5in;
mso-add-space:auto;
text-indent:-.5pt;
line-height:122%;
font-size:12.0pt;
font-family:"Verdana",sans-serif;
color:black;}
span.EmailStyle17
{mso-style-type:personal-compose;
font-family:"Times New Roman",serif;
font-variant:normal !important;
color:black;
text-transform:none;
font-weight:normal;
font-style:normal;
text-decoration:none none;
vertical-align:baseline;}
p.normaltext, li.normaltext, div.normaltext
{mso-style-name:normaltext;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:12.0pt;
font-family:"Times New Roman",serif;}
span.apple-converted-space
{mso-style-name:apple-converted-space;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:12.0pt;
font-family:"Calibri",sans-serif;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
/* List Definitions */
@list l0
{mso-list-id:828399899;
mso-list-type:hybrid;
mso-list-template-ids:491920122 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}
@list l0:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l0:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l0:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l0:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.75in;
text-indent:-.25in;
font-family:Symbol;}
@list l0:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.25in;
text-indent:-.25in;
font-family:"Courier New";}
@list l0:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.75in;
text-indent:-.25in;
font-family:Wingdings;}
@list l0:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l0:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l0:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:4.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l1
{mso-list-id:880242055;
mso-list-type:hybrid;
mso-list-template-ids:94538584 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}
@list l1:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l1:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l1:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l1:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.75in;
text-indent:-.25in;
font-family:Symbol;}
@list l1:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.25in;
text-indent:-.25in;
font-family:"Courier New";}
@list l1:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.75in;
text-indent:-.25in;
font-family:Wingdings;}
@list l1:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l1:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l1:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:4.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l2
{mso-list-id:1092706656;
mso-list-type:hybrid;
mso-list-template-ids:-756410946 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}
@list l2:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l2:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l2:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l2:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.75in;
text-indent:-.25in;
font-family:Symbol;}
@list l2:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.25in;
text-indent:-.25in;
font-family:"Courier New";}
@list l2:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.75in;
text-indent:-.25in;
font-family:Wingdings;}
@list l2:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l2:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l2:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:4.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l3
{mso-list-id:1396125638;
mso-list-type:hybrid;
mso-list-template-ids:1393466812 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}
@list l3:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:18.5pt;
text-indent:-.25in;
font-family:Symbol;}
@list l3:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:54.5pt;
text-indent:-.25in;
font-family:"Courier New";}
@list l3:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:90.5pt;
text-indent:-.25in;
font-family:Wingdings;}
@list l3:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:126.5pt;
text-indent:-.25in;
font-family:Symbol;}
@list l3:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:162.5pt;
text-indent:-.25in;
font-family:"Courier New";}
@list l3:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:198.5pt;
text-indent:-.25in;
font-family:Wingdings;}
@list l3:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:234.5pt;
text-indent:-.25in;
font-family:Symbol;}
@list l3:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:270.5pt;
text-indent:-.25in;
font-family:"Courier New";}
@list l3:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:306.5pt;
text-indent:-.25in;
font-family:Wingdings;}
@list l4
{mso-list-id:1665744191;
mso-list-type:hybrid;
mso-list-template-ids:-1659057606 67698689 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;}
@list l4:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l4:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l4:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.25in;
text-indent:-.25in;
font-family:Wingdings;}
@list l4:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:1.75in;
text-indent:-.25in;
font-family:Symbol;}
@list l4:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.25in;
text-indent:-.25in;
font-family:"Courier New";}
@list l4:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:2.75in;
text-indent:-.25in;
font-family:Wingdings;}
@list l4:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.25in;
text-indent:-.25in;
font-family:Symbol;}
@list l4:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:3.75in;
text-indent:-.25in;
font-family:"Courier New";}
@list l4:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:none;
mso-level-number-position:left;
margin-left:4.25in;
text-indent:-.25in;
font-family:Wingdings;}
ol
{margin-bottom:0in;}
ul
{margin-bottom:0in;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal" style="margin:0in;text-indent:0in;line-height:115%"><span style="font-size:18.0pt;line-height:115%;font-family:"Calibri",sans-serif;color:#548235">Xenbase Newsletter Fall-Winter 2020-21<o:p></o:p></span></p>
<p class="MsoNormal" style="margin:0in;text-indent:0in;line-height:115%"><span style="font-size:18.0pt;line-height:115%;font-family:"Calibri",sans-serif;color:#548235"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in;text-indent:0in;line-height:115%"><span style="font-size:18.0pt;line-height:115%;font-family:"Calibri",sans-serif;color:#548235">Introducing<b> Xenbase v5.0 </b>including Phenotypes, a new look and integrated
<i>X. tropicalis</i> v10.0 genome.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><span style="font-size:16.0pt;line-height:122%;font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:normal">
<b><i><span style="font-size:5.0pt;font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></i></b></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:115%">
<b><i><span style="font-size:14.0pt;line-height:115%;font-family:"Segoe UI",sans-serif">Xenopus</span></i></b><b><span style="font-size:14.0pt;line-height:115%;font-family:"Segoe UI",sans-serif"> Phenotypes now live!<o:p></o:p></span></b></p>
<p class="normaltext" style="margin:0in;text-align:justify"><b><span style="font-family:"Segoe UI",sans-serif">Anatomy Phenotypes</span></b><span style="font-family:"Segoe UI",sans-serif">, e.g., phenotypes of gross morphology, organ, tissue, cellular and molecular
changes or aberrant behavior, are now curated from published articles.<b> Manual
<u>E</u>xpression <u>P</u>henotype</b> (aka EP) captures the vast amount of <i>Xenopus</i> data from
<i><span style="color:#538135">changes in gene expression</span></i> from ISH and IHC data. Similarly up and down regulated gene expression identified in high throughput sequencing projects (e.g., RNA-Seq) from GEO as captured as
<b>Computed Expression Phenotypes</b>. <span style="color:black">Phenotypes are curated from a wide range of experiments including morpholino, TALEN and CRISPR gene knockout/knockdown, transgenes and mutations, effects of toxins, reagents and drugs, and other
experimental perturbations and stressors. Curation is ongoing, and more data is added every day, with our highest priority being
<i>Xenopus</i> models of human disease. <o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:normal">
<span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;line-height:normal">
<span style="font-family:"Segoe UI",sans-serif;color:#111111">Explore the <b>Phenotype Search</b>
</span><a href="https://www.xenbase.org/common/searchPhenotype.do?method=display"><span style="font-family:"Segoe UI",sans-serif">here</span></a><span class="apple-converted-space"><span style="font-family:"Segoe UI",sans-serif;color:#111111"> .</span><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:normal;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:#111111">Searching phenotypes is easy - just enter any gene symbol or tissue, organ, or cell type to find relevant phenotype data.</span><o:p></o:p></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:normal;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-family:Symbol;color:#111111"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:#111111">Disease models can be searched by disease name or their associated gene(s)<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:150%;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-family:Symbol;color:#111111"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:#0070C0">A video tutorial showing you how to navigate around Phenotypes is coming soon!</span><span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:115%">
<span style="font-family:"Segoe UI",sans-serif;color:#111111">Need help? Click<span class="apple-converted-space"> </span></span><a href="https://www.xenbase.org/other/static-xenbase/phenotypesHelp.jsp"><span style="font-family:"Segoe UI",sans-serif">here</span></a><span class="apple-converted-space"><span style="font-family:"Segoe UI",sans-serif;color:#111111"> </span></span><span style="font-family:"Segoe UI",sans-serif;color:#111111">for
a quick guide to the Phenotype Search. <o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:150%">
<span class="apple-converted-space"><span style="font-family:"Segoe UI",sans-serif;color:#111111">Contact us with questions or feedback:
</span></span><a href="mailto:Xenbase@ucalgary.ca"><span style="font-family:"Segoe UI",sans-serif">Xenbase@ucalgary.ca</span></a><span class="apple-converted-space"><o:p></o:p></span></p>
<p class="MsoListParagraph" style="margin-left:0in;mso-add-space:auto;text-indent:0in;line-height:normal">
<span style="font-size:10.5pt;font-family:"Segoe UI",sans-serif;color:#0070C0">Thanks to our volunteer Phenotype beta-testers who provide insights and feedback. Thank you Jessica, Cindy, Robb, Scott, Margaret, Nicole, Pai, Agustin, Peter, Thomas, Maria-Belén
and Dan,!</span><span style="font-size:10.5pt;color:#0070C0"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;line-height:normal"><span style="font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><b><span style="font-size:14.0pt;line-height:122%;font-family:"Segoe UI",sans-serif;color:#111111">New Xenbase Homepage Design<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:0in;line-height:normal"><span style="font-family:"Segoe UI",sans-serif">Our redesigned
</span><a href="http://www.xenbase.org/"><span style="font-family:"Segoe UI",sans-serif">homepage</span></a><span style="font-family:"Segoe UI",sans-serif"> has a cleaner look and more stream-lined menus and links.
<b> </b></span><span style="font-family:"Segoe UI",sans-serif;color:#111111">We hope you like it!
</span><span style="font-family:"Segoe UI",sans-serif">Changes to note:<b><o:p></o:p></b></span></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">The
<b>Quick Search</b> is now across the top of the homepage.<b><o:p></o:p></b></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">News, announcements and article spotlight still in front and center in the rotating carousel.<b><o:p></o:p></b></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">A new tile for
<b>Phenotypes & Disease Models</b>. <o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol;color:#111111"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><b><span style="font-family:"Segoe UI",sans-serif">Genomes & Genomics</span></b><span style="font-family:"Segoe UI",sans-serif">,
<b>Gene Expression</b>, <b>Anatomy & Development</b> tiles collate the most used resources.</span><b><span style="font-family:"Segoe UI",sans-serif;color:#111111">
</span></b><span style="font-family:"Segoe UI",sans-serif;color:#111111"> <o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol;color:#111111"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><b><span style="font-family:"Segoe UI",sans-serif;color:#111111">Literature</span></b><span style="font-family:"Segoe UI",sans-serif;color:#111111">,
<b>Community</b>, <b>Reagents & Protocols</b>, <b>Stock Centers </b>are all now accessed from the lower panel) as well as general information about Xenbase and
<i>Xenopus </i>as a model.<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l2 level1 lfo2">
<![if !supportLists]><span style="font-family:Symbol;color:#111111"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:#111111">All content is available via drop down menus in the header as before.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:115%">
<span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><span style="font-family:"Segoe UI",sans-serif;color:#111111">Our designed homepage is cleaner, less cluttered and makes room for new features.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in;line-height:115%">
<span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><img border="0" width="672" height="512" style="width:7.0in;height:5.3333in" id="Picture_x0020_4" src="cid:image001.png@01D6C292.A47875E0" alt="Graphical user interface, text
Description automatically generated"><span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><img border="0" width="674" height="275" style="width:7.0208in;height:2.8645in" id="Picture_x0020_45" src="cid:image002.png@01D6C292.A47875E0" alt="Graphical user interface, application
Description automatically generated"><b><span style="font-size:14.0pt;line-height:122%;font-family:"Segoe UI",sans-serif"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><b><span style="font-size:14.0pt;line-height:122%;font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><b><span style="font-size:14.0pt;line-height:122%;font-family:"Segoe UI",sans-serif">Latest
<i>X. tropicalis</i> v10.0 genome is now fully integrated in Xenbase.</span></b><span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left:18.5pt;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l3 level1 lfo3">
<![if !supportLists]><span style="font-family:Symbol;color:black"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:black">The new
<i>X. tropicalis</i> v10.0 genome is everywhere it should be across Xenbase- on the Gene Pages, as an option BLAST, on JBrowse and GBrowse, and incorporated on MO pages.
<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:18.5pt;mso-add-space:auto;text-align:justify;text-indent:0in;line-height:115%">
<img border="0" width="698" height="120" style="width:7.2708in;height:1.25in" id="Picture_x0020_43" src="cid:image003.png@01D6C292.A47875E0" alt="A picture containing graphical user interface
Description automatically generated"><span style="font-family:"Segoe UI",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;text-align:justify;text-indent:0in;line-height:normal">
<b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;text-align:justify;text-indent:0in;line-height:normal">
<b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif">Improvements to
</span></b><b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif;color:black">Morpholino</span></b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif;color:black">
</span><b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif">Pages <o:p>
</o:p></span></b></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l4 level1 lfo4">
<![if !supportLists]><span style="font-family:Symbol;color:black"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:black">Morpholinos are now aligned to
<i>X. tropicalis</i> v10.0 and <i>X. laevis</i> v9.2 to show </span><span style="font-family:"Segoe UI",sans-serif;color:#538135">target
</span><span style="font-family:"Segoe UI",sans-serif;color:black">and </span><span style="font-family:"Segoe UI",sans-serif;color:#FF40FF">off-target
</span><span style="font-family:"Segoe UI",sans-serif;color:black">hits. </span><i><span style="font-family:"Segoe UI",sans-serif;color:#0070C0">Did you know there are 2670 Xenopus MOs in Xenbase ?</span></i><i><span style="font-family:"Segoe UI",sans-serif;color:black"><o:p></o:p></span></i></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:18.5pt;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l3 level1 lfo3">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:black">Morpholino JBrowse track is now available for both
<i>X. tropicalis</i> v10.0 and <i>X. laevis</i> v9.2.</span><span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:18.5pt;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:115%;mso-list:l3 level1 lfo3">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">Morpholino pages also have a snapshot of the MO aligned to new genomes.</span><span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><img border="0" width="696" height="381" style="width:7.25in;height:3.9687in" id="Picture_x0020_47" src="cid:image005.png@01D6C292.A47875E0" alt="A picture containing timeline
Description automatically generated"><span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;line-height:150%">
<b><span style="font-size:14.0pt;line-height:150%;font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;line-height:150%">
<b><span style="font-size:14.0pt;line-height:150%;font-family:"Segoe UI",sans-serif">Improvements to Gene Pages<o:p></o:p></span></b></p>
<p class="MsoListParagraphCxSpFirst" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:150%;mso-list:l1 level1 lfo5">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif;color:windowtext">Link to CRISPRscan tracks (Guide RNAs for Coding regions) and available Mutant lines (from NXR and EXRC) now listed as Reagents on Gene Pages.<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.25in;mso-add-space:auto;text-indent:-.25in;line-height:150%;mso-list:l1 level1 lfo5">
<![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">Rat orthologues added with links to the Rat Genome Database (RGD).<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.25in;mso-add-space:auto;text-indent:-.25in;line-height:150%;mso-list:l1 level1 lfo5">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">UniProt proteins and InterPro Links now on Gene Page/Protein tab.</span><span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:150%;mso-list:l1 level1 lfo5">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">More Disease resources (see External Links) added to summary: COSMIC, MARRVEL, GTR, dbVAR, GHR and gnomAD.</span><span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:0in;margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:150%;mso-list:l1 level1 lfo5">
<![if !supportLists]><span style="font-family:Symbol;color:windowtext"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Segoe UI",sans-serif">Gene Pages for all mtDNA genes and mitochondrial tRNAs.
</span><span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p></o:p></span></p>
<p style="text-align:justify;background:white"><span style="color:black"><img border="0" width="672" height="279" style="width:7.0in;height:2.9062in" id="Picture_x0020_48" src="cid:image006.png@01D6C292.A47875E0" alt="Graphical user interface, text, application, email
Description automatically generated"></span><span class="apple-converted-space"><b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif;color:#111111"><o:p></o:p></span></b></span></p>
<p style="text-align:justify;background:white"><span class="apple-converted-space"><b><span style="font-size:14.0pt;font-family:"Segoe UI",sans-serif;color:#111111">Citing Xenbase<o:p></o:p></span></b></span></p>
<ul type="disc">
<li style="color:#212529;margin-left:-.25in;text-align:justify;mso-list:l1 level1 lfo5;background:white">
<span class="apple-converted-space"><span style="font-family:"Segoe UI",sans-serif;color:#111111">If you use Xenbase, please cite us in your papers.
</span></span><span style="font-family:"Segoe UI",sans-serif">Xenbase (http://www.xenbase.org/, RRID:SCR_003280)</span><o:p></o:p></li><li style="color:#212529;margin-left:-.25in;text-align:justify;mso-list:l1 level1 lfo5;background:white">
<b><i><span style="font-family:"Segoe UI",sans-serif">General article on Xenbase:</span></i></b><i><span style="font-family:"Segoe UI",sans-serif"> Karimi et al. 2018,<span class="apple-converted-space"> </span>NAR 46:D1:D861-868, doi:10.1093/nar/gkx936.<o:p></o:p></span></i></li><li style="color:#111111;margin-left:-.25in;text-align:justify;mso-list:l1 level1 lfo5;background:white">
<b><i><span style="font-family:"Segoe UI",sans-serif;color:#212529">GEO data:</span></i></b><i><span style="font-family:"Segoe UI",sans-serif;color:#212529"> Fortriede et al. 2020,<span class="apple-converted-space"> </span>NAR 48:D1:D776–782. doi:10.1093/nar/gkz933
</span></i><i><span style="font-family:"Segoe UI",sans-serif"><o:p></o:p></span></i></li></ul>
<p class="MsoListParagraph" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:-.25in;line-height:normal;mso-list:l1 level1 lfo5">
<![if !supportLists]><span class="apple-converted-space"><span style="font-family:Symbol;color:#212529"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span></span><![endif]><b><i><span style="font-family:"Segoe UI",sans-serif;color:#212529">Disease Research</span></i></b><i><span style="font-family:"Segoe UI",sans-serif;color:#212529">: Nenni et al. 2019,<span class="apple-converted-space"> </span>Frontiers
in Physiology, Vol.10, doi:10.3389/fphys.2019.00154 </span></i><span class="apple-converted-space"><span style="color:#212529"><o:p></o:p></span></span></p>
<ul type="disc">
<li style="color:#111111;margin-left:-.25in;text-align:justify;mso-list:l1 level1 lfo5;background:white">
<span class="apple-converted-space"><span style="font-family:"Segoe UI",sans-serif">Impressed? Find a bug? Contact us with comments, questions or feedback:
</span></span><span style="color:black"><a href="mailto:Xenbase@ucalgary.ca"><span style="font-family:"Segoe UI",sans-serif">Xenbase@ucalgary.ca</span></a></span><o:p></o:p></li></ul>
<p class="MsoListParagraphCxSpFirst" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:0in">
<span style="font-size:16.0pt;line-height:122%;font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left:.25in;mso-add-space:auto;text-align:justify;text-indent:0in">
<span style="font-size:16.0pt;line-height:122%;font-family:"Segoe UI",sans-serif;color:#111111">Can’t see the figures in your email? See attached pdf. Click this link to see the new look Xenbase homepage:
<a href="http://www.Xenbase.org">www.Xenbase.org</a><o:p></o:p></span></p>
<p class="MsoNormal" style="margin:0in;text-align:justify;text-indent:0in;line-height:150%">
<span style="font-family:"Segoe UI",sans-serif;color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-align:justify;text-indent:0in"><span style="font-family:"Segoe UI",sans-serif;color:#111111"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:0in"><span style="line-height:122%;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
</div>
</body>
</html>