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<p class="MsoNormal"><span style="font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:black">Dear Xenopus researchers,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:black">Our apologies if this request comes to you multiple times- we have reached out individually to all those who attended the XRET meeting, and last year’s IXC, but we’ erhoping this Xine email list may include a few
more people who haven’t heard from us! So please read this email- and reply! </span>
<span style="color:black;mso-ligatures:none">This is important! </span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="color:black;mso-ligatures:none"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="color:black;mso-ligatures:none">The renewal of the Xenbase grant (P41 HD064556, from the NICHD) is due in January 2025. </span></b><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;background:yellow;mso-highlight:yellow;mso-ligatures:none">If the continued existence of Xenbase is important for your research, we ask you to <b>send us a Letter of Support by Dec. 16<sup>th,</sup> 2024.</b></span><b><span style="color:black;mso-ligatures:none">
Email us : <a href="mailto:xenbase@cchmc.org">xenbase@cchmc.org</a><o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none">Since we will be collecting many letters, <b>we need you to write the letter in your own words</b><i>.</i> To make this as easy as possible, we suggest some topics to cover in the letter template
included below. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none">Many thanks for your continued support,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none">Yours sincerely,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none">Aaron Zorn & Peter Vize<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-ligatures:none"> Directors, Xenbase<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"><img border="0" width="204" height="39" style="width:2.125in;height:.4062in" id="Picture_x0020_4" src="cid:image001.png@01DB2E9E.EA4D0C30" alt="signature_809005874"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"><a href="https://urldefense.com/v3/__http:/www.xenbase.org__;!!DZ3fjg!9RVFx_dopubGa5TmXjNdRjYBHfSL7cOxV6mOCA5_S2a00kDQiITse1FvZsqg4Zf6ZQrZaIlm9dO7H2G-7w$" title="https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefense.com%2Fv3%2F__http%3A%2Fwww.xenbase.org__%3B!!DZ3fjg!9RVFx_dopubGa5TmXjNdRjYBHfSL7cOxV6mOCA5_S2a00kDQiITse1FvZsqg4Zf6ZQrZaIlm9dO7H2G-7w%24&data=05%7C02%7Cxenbase%40cchmc.org%7C9e9">www.xenbase.org</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">Template Letter of Support for Xenbase:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">Address LoS to:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">Drs. Aaron Zorn and Peter Vize,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">Directors, Xenbase<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Express your support for the Xenbase renewal.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Mention how the renewal of Xenbase funding was identified as the most critical, immediate need of the <i>Xenopus </i>Research
Community at the October 2024 XRET meeting and in the 2025 White Paper (to be out soon).<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Briefly describe your research, listing previous and current NIH grant support (or any NIH funded collaborations). <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Explain how vital access to Xenbase is to your research and/or teaching. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Describe which features of Xenbase your lab uses and how frequently you/your trainees use Xenbase (how many times a day/week?). <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Possible features to emphasize include the availability to the most up-to-date genomes and genomics, support for human disease
modeling, & our data sharing infrastructure, help desk and tutorials/workshops.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• How does Xenbase compare to other model organism databases that you use?<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">• Finally, explain how your research would be impacted if Xenbase ceased to exist. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">Don’t forget to sign your name, and include in your full name, email and affiliation, and please print this LoS on your institutional letter
head if possible. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none">THANK YOU!<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;mso-ligatures:none"> <o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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