[Xenopus] Xenopus mutant survey

Marko Horb mhorb at mbl.edu
Wed Sep 10 11:30:24 EDT 2014

Hi All, 
I realize it has only been two days since I sent this email, but I am a bit concerned by the lack of responses- I have only received 12. If I don't get more responses then I will probably not write the grant. I need the responses immediately as there is only 2 weeks left for me to write the grant. However, if the community is not sufficiently interested in the generation of mutants then it becomes a fruitless endeavor. 
So please response ASAP. 



----- Original Message -----

From: "National Xenopus Resource" <xenopus at mbl.edu> 
To: xenopus at lists.mbl.edu 
Sent: Monday, September 8, 2014 12:07:40 PM 
Subject: [Xenopus] Xenopus mutant survey 

Dear Xenopus colleagues 
Following the successful conference in Asilomar I am preparing an R01 application for the Xenopus PAR deadline at the end of this month focusing on generating 100 Xenopus mutants using CRISPR/Cas or TALEN in Xenopus tropicalis or Xenopus laevis. These are mutants that you would like made. The goal is to make F0 or F1 heterozygous mutant animals in specific genes and have the adults available for purchase. But in order for this to be successful I need your support. Since the NIH has an emphasis on animal models of human disease I am asking you to link your desired gene mutation with a specific human disease. I have drafted a committee of individuals from diverse fields to help prioritize the mutants so as not to exclude areas of research. This is a long term plan but one we should all support. Much like other systems the goal should be to mutate all genes, but we will start with a smaller number. If this interests you I have two requests 

First , complete the survey as soon as possible so I can compile the list and include it in the grant. The survey is found at this URL: 


Second , I also ask that you send me letters of support for this project to include in the application. In this letter please address the necessity of such a project, your specific interests and how this will benefit the entire community and should be supported. 

Thank you for your support and I look forward to working with you in making the mutants. 

Marko Horb 

P.S. The custom mutant service the NXR provides is still the best option if you want a mutant sooner rather than later. 

Marko Horb, Ph.D. 
Director, National Xenopus Resource (NXR) 
Marine Biological Laboratory 
7 MBL Street 
Woods Hole, MA 02543 

Email: xenopus at mbl.edu 
Office: 508-289-7627 
Cell: 508-564-3764 


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